The a16z Show

John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

Tue, 28 Apr 2026 10:00:00 +0000

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and why the economics of software are shifting from mass-produced products to bespoke, on-demand systems cooked fresh at the moment of use.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Ben Horowitz on Venture Capital and AI

content+a16zpodcast@a16z.com (Ben Horowitz, Anjney Midha) — Mon, 27 Apr 2026 10:05:18 +0000

Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven business into a scalable system for backing new technology companies. They discuss network effects, firm design, leadership, culture, and how AI is reshaping both the capital race and the kinds of companies that can be built now.

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AI Inside the Enterprise

Fri, 24 Apr 2026 10:00:00 +0000

Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and the rest of the world, why most AI initiatives fail in large organizations, and how agents, infrastructure, and workflows are evolving beyond the hype.

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Martin Shkreli on AI, Pharma, and What Actually Matters

content+a16zpodcast@a16z.com (Erik Torenberg, Martin Shkreli) — Thu, 23 Apr 2026 15:34:18 +0000

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right.

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Balaji Srinivasan: Prove Correct, Not Just Go Direct

content+a16zpodcast@a16z.com (Erik Torenberg, Theo Jaffee, Balaji Srinivasan) — Wed, 22 Apr 2026 10:00:00 +0000

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They discuss why systems like hiring, journalism, and online communication are breaking under synthetic content, and what replaces them. The conversation also examines the role of cryptography, on-chain data, and new models of proof in rebuilding trust online.

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